World Health Organization

---

Six months into a pandemic that has killed over half a million  people, more than 200 scientists from around the world are challenging  the official view of how the coronavirus spreads.

The  World Health Organization and the U.S. Centers for Disease Control and  Prevention maintain that you have to worry about only two types of  transmission: inhaling respiratory droplets from an infected person in your immediate vicinity or — less common — touching a contaminated surface and then your eyes, nose or mouth.

But  other experts contend that the guidance ignores growing evidence that a  third pathway also plays a significant role in contagion.

They say multiple studies demonstrate that particles known as aerosols — microscopic versions of standard respiratory droplets — can hang in the air for long periods and float dozens of feet, making poorly ventilated  rooms, buses and other confined spaces dangerous, even when people stay  six feet from one another.

“We are 100% sure about this,” said Lidia Morawska,  a professor of atmospheric sciences and environmental engineering at  Queensland University of Technology in Brisbane, Australia.

She  makes the case in an open letter to the WHO accusing the United Nations  agency of failing to issue appropriate warnings about the risk. A total  of 239 researchers from 32 countries signed the letter, which is set to  be published next week in a scientific journal.

In interviews,  experts said that aerosol transmission appears to be the only way to  explain several “super-spreading” events, including the infection of diners at a restaurant in China who sat at separate tables and of choir members in Washington state who took precautions during a rehearsal.

WHO officials have acknowledged that the virus can be transmitted through aerosols but say that occurs only during medical procedures such as intubation that can spew large quantities of the microscopic particles. CDC officials did not respond to multiple requests for comment.

Dr. Benedetta Allegranzi,  a top WHO expert on infection prevention and control, said in responses  to questions from The Times that Morawska and her group presented  theories based on laboratory experiments rather than evidence from the  field.

“We value and respect their opinions and contributions to  this debate,” Allegranzi wrote in an email. But in weekly  teleconferences, a large majority of a group of more than 30  international experts advising the WHO has "not judged the existing evidence sufficiently convincing to consider airborne transmission as having an important role in COVID-19 spread."

She added that such transmission “would have resulted in many more cases and even more rapid spread of the virus.”

Since  the coronavirus was first detected in China in December, understanding  of how it spreads has evolved considerably, resulting in shifting guidelines regarding the use of masks.

At  first, the WHO and CDC said masks were overkill for ordinary people and  should be conserved for health workers. Later, the CDC recommended  masks only for people with COVID-19 symptoms.

Then in April, after it became clear that people without symptoms could also spread the virus, the CDC suggested masks for everybody when physical distancing was difficult, a position the WHO eventually adopted.

Now  as outbreaks proliferate and governors order a new round of closures,  nearly all U.S. states have made face coverings mandatory or recommended  them, primarily to prevent wearers from spreading the disease.

The proponents of aerosol transmission said masks worn correctly would help prevent the escape of exhaled aerosols as well as inhalation of the microscopic particles. But they said the  spread could also be reduced by improving ventilation and zapping indoor  air with ultraviolet light in ceiling units.

Jose Jimenez,  a University of Colorado chemist who signed the letter, said the idea  of aerosol transmission should not frighten people. "It's not like the  virus has changed," he said. "We think the virus has been transmitted  this way all along, and knowing about it helps protect us."

He and other scientists cited several studies supporting the idea that aerosol transmission is a serious threat.

As  early as mid-March, a study in the New England Journal of Medicine  found that when the virus was suspended in mist under laboratory  conditions it remained “viable and infectious” for three hours, which  researchers said equated to as much as half an hour in real-world  conditions.

It had already been established that some people,  known as “super spreaders,” happen to be especially good at exhaling  fine material, producing 1,000 times more than others.

A recent  study found coronavirus RNA in hallways near hospital rooms of COVID-19  patients. Another raised concerns that aerosols laden with the virus  were shed by floor-cleaning equipment and by health workers removing  personal protective gear.

Researchers in China found evidence of aerosols containing the coronavirus in two Wuhan hospitals.

It was the outbreak among choir members in Mount Vernon, Wash. — and a report about the incident in The Times — that first piqued the interest of several of the aerosol  proponents. Of 61 singers at a March 10 rehearsal, all but eight became  sick, despite the members using hand sanitizer and avoiding hugging or  shaking hands. Two people died.

A team led by Shelly Miller,  a University of Colorado professor of mechanical engineering, dug into  church-hall blueprints, furnace specifications, locations of choir  members and hours of attendance. The researchers diagrammed movements of  the singer who was identified as the person who unwittingly brought the  virus to practice.

Inhalation of aerosols “most likely dominated infection transmission during this event,” the researchers wrote in a paper undergoing peer review, concluding that the ill person, who had  symptoms similar to a common cold, was unlikely to have spent time  within six feet of many singers or to have touched surfaces in common  with them.

“We believe it likely that shared air in the fellowship  hall, combined with high emissions of respiratory aerosol from singing,  were important contributing factors,” the paper said.

Eventually  researchers from a broad spectrum of disciplines, including several who  have studied the role of aerosols in the spread of the flu, SARS and other infectious diseases, joined forces to campaign for greater recognition of aerosol transmission.

They  said that the coronavirus is less contagious through the air than  measles but that the risk of transmission goes up the longer air remains  stagnant and the longer people continue to breathe it.

In  interviews, they said WHO officials had unfairly set a higher bar for  showing aerosol spread than was required for acceptance of the other two  pathways. “For them, droplets and touch are so obvious that they’re  proven, but airborne is so outlandish that it needs a very high level of  evidence,” Jimenez said.

Proof would require exposing large  numbers of healthy people to aerosols emitted by COVID-19 patients, a  study that scientists said would be unethical.

Donald Milton, a University of Maryland environmental health professor and an expert on aerosols who co-wrote the letter, said the average person breathes 10,000 liters of air each day.

"You  only need one infectious dose of the coronavirus in 10,000 liters, and  it can be very hard to find it and prove that it’s there, which is one  of the problems we’ve had,” he said.